PROJECT MEMBERS

Collaborators:

  • Maria Coats
  • (School of Medicine, Ninewells, Dundee)

  • Frank Carey
  • (Department of Pathology, Ninewells, Dundee)

Optical Projection Tomography of Colorectal Polyps
Colorectal cancer is the second most commonly diagnosed cancer in the UK. Screening has reduced mortality and detected large numbers of adenomas and polypoid cancers. Diagnosis of these lesions shows marked inter-observer variation using conventional 2D histopathology. Optical Projection Tomography (OPT) is a whole-mount in vitro imaging technology that produces 3D images. We are developing algorithms for quantitative analysis of OPT images of premalignant colorectal polyps, focusing on histological features of potential clinical utility. This project is in collaboration with the School of Medicine at Ninewells Hospital, Dundee (Coats, Carey) and has received funding from the Dundee Cancer Centre.
Publications
2014
[4] J. Zhang, J. Zhang, M. Coats, F. Carey, S. J. McKenna,
"Analysing the Surface Morphology of Colorectal Polyps: Differential Geometry and Pit Pattern Prediction", in Medical Image Understanding and Analysis (MIUA), 2014, pp. 67-72. [bib] [pdf]
2013
[3] W. Li, M. Coats, J. Zhang, S. J. McKenna,
"Comparative Analysis of Feature Extraction Methods for Colorectal Polyp Images in Optical Projection Tomography", in Medical Image Understanding and Analysis (MIUA), 2013, pp. 67-72. [bib] [pdf]
[2] W. Li, J. Zhang, W. Zheng, M. Coats, F. A. Carey, S. J. McKenna,
"Learning from Partially Annotated OPT Images by Contextual Relevance Ranking", in International Conference on Medical Image Computing and Computer Assisted Intervention (MICCAI), Nagoya, Japan (In Press), 2013. [bib] [pdf]
[1] W. Li, J. Zhang, S. J. McKenna, M. Coats, F. A. Carey,
"Classification of colorectal polyp regions in optical projection tomography", in International Symposium on Biomedical Imaging (ISBI), San Francisco, 2013. [bib] [pdf]
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