Detection of ischemia in ultra-wide-field-of-view retinal fluorescein angiograms

Fluorescein angiography is used to examine the retinal vasculature using dye tracing. A typical exam generates tens of images showing increasing portions of the retinal vasculature as they are perfused by a constrast medium (fluorescein). We work with OPTOS plc, manufacturer of world-leading scanning laser ophthalmoscopes, and clinical centres in the UK and the US (e.g., the Jules Stein Eye Research Institute, San Diego) towards summarization of retinal angiographic exams. Our software registers all images in the angiogram robustly, then locates and quantifies key lesions like leaking vessels and ischemic regions. Special challenges are posed by the size of the images from OPTOS instruments (about 3,000x3,000 pixels), covering more than 200° of the retina horizontally, and by the continuous change of image contents typical of an angiographic sequence, making the search for robust correspondence between images difficult.
Publications
2013
[3] K. Zutis, E. Trucco, J. Hubschman, D. Reed, S. Shah, J. v. Hemert,
"Towards Automatic Detection of Abnormal Retinal Capillaries in Ultra-Widefield-of-View Retinal Angiographic Exams", in 35th Annual International Conference of the IEEE EMBS Engineering in Medicine and Biology Society (EMBC), Osaka, Japan, 2013, pp. 7372-7375. [bib] [pdf]
2007
[2] E. Trucco, C. Buchanan, T. Aslam, B. Dhillon,
"Contextual detection of ischemic regions in ultra-wide-field-of-view fluorescein angiograms", in Medical Image Understanding and Analysis (MIUA), 2007. [bib]
[1] E. Trucco, C. Buchanan, T. Aslam, B. Dhillon,
"Contextual detection of ischemic regions in ultra-wide-field-of-view fluorescein angiograms", in International Conference on Engineering in Medicine and Biology (EMBC), 2007. [bib] [pdf]
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